This study aimed to determine what the effect of participation in a Tomatis® Programme (TP) would be on the psychological well-being and communication ability of a 14 year old, white adolescent boy with Asperger Disorder (AD). A mixed method design in the form of a single case study was used. Qualitative data were obtained via semi-structured interviews, spontaneous sketches and observation. Quantitative data were gathered by means of projective drawings and the Profile of Mood States (POMS). Seven main categories with twenty-one sub-categories emerged eom the qualitative data, and were supported by the quantitative data. Results indicated improvement in Interpersonal Communication and all six domains of psychological well-being as defined by RyfT (1995) with most significant areas being: Environmental Mastery, Personal Growth, Autonomy and Positive Relations. The Tomatis® Method (TM) proved to be a successful form of treatment to enhance psychological well-being and interpersonal communication skills in an AD patient. More effective communication and better family relationships can be achieved and therefore youth with AD can be empowered to adjust their behavior accordingly. The TM prepared the participant for a next phase in therapy where he specifically can focus on more effective social skills with peers. Further research involving more participants and a control group is needed.